Communication Bridge: Optimizing an Evidence-based Intervention for Individuals With Primary Progressive Aphasia

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Phase 2
SUMMARY

This study will use a randomized controlled trial design to evaluate the effect of two evidence-based treatments for adults with mild-moderate Primary Progressive Aphasia (PPA). The aim of the study is to help us better understand the effects of speech-language therapy on communication abilities in individuals with PPA.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 100
Healthy Volunteers: f
View:

• Meets diagnostic criteria for PPA based on neurologist and supporting medical assessments (extracted from medical records)

• English as primary language used in daily communication activities (by self-report)

• Adequate hearing (aided or unaided) for communicating with others in a crowded room (by self-report)

• Adequate vision (aided or unaided) for reading a newspaper, or other functional materials (by self-report)

• Able to pass technology screening and demonstrates sufficient knowledge for use of video conference and Communication Bridge™ web application use (with or without training)

• Geriatric Depression Scale score ≤ 9

• Mild-moderate PPA informed by a structured interview with a speech-language pathologist and a standardized testing battery.

• 18+ years of age

• English as primary language used in daily communication activities (by self-report)

• Adequate hearing (aided or unaided) for communicating with others in a crowded room (by self-report)

• Able to pass technology screening\* and demonstrates sufficient knowledge for use of video conference and Communication Bridge™ web application use (with or without training)

Locations
United States
Illinois
University of Chicago - American School Building
RECRUITING
Chicago
Contact Information
Primary
Matthew Bona, MPH
cbtrial@uchicago.edu
773-702-1220
Backup
Emily Cummings
cbtrial@uchicago.edu
773-702-1221
Time Frame
Start Date: 2024-08-23
Estimated Completion Date: 2028-07-15
Participants
Target number of participants: 200
Treatments
Experimental: Communication Bridge™
Participants receive Communication Bridge™, a multi-component, participation-focused, dyadic intervention in which both the person with PPA and their co-enrolled communication partner are intervention recipients. Communication Bridge™ is modelled on the Living with Aphasia: Framework for Outcome Measurement (A-FROM) and the Care Pathway Model that was developed for persons living with primary progressive aphasia. Consistent with participation-focused intervention models personally salient training stimuli are incorporated into all therapy activities in the Experimental arm.
Active_comparator: Evidence-Based Impairment Focused
The Control arm includes a non-dyadic intervention in which the person with PPA is the active intervention recipient and their communication partner is in a supporting role. In the Control arm, participants receive a speech-language intervention designed to address impairment and functional limitations, comprised of activities that address word retrieval and 'automatic' speech production using fixed, non-personalized, stimuli across participants.
Related Therapeutic Areas
Sponsors
Leads: University of Chicago
Collaborators: National Institute on Aging (NIA), Western University, Canada

This content was sourced from clinicaltrials.gov